Dysoxia and lactate

Dysoxia and lactate.

Disturbances of oxygen supply or cellular oxygen metabolism are common in critically ill patients. An understanding of dysoxia, or oxygen limited energy depletion, requires an understanding of the normal physiology of cell oxygen metabolism, and the compensatory mechanisms that supply high energy molecules under conditions of hypoxia. Understanding disorders associated with hyperlactataemia req...

Renal hypoxia and dysoxia after reperfusion of the ischemic kidney.

Ischemia is the most common cause of acute renal failure. Ischemic-induced renal tissue hypoxia is thought to be a major component in the development of acute renal failure in promoting the initial tubular damage. Renal oxygenation originates from a balance between oxygen supply and consumption. Recent investigations have provided new insights into alterations in oxygenation pathways in the isc...

Renal Hypoxia and Dysoxia following Reperfusion of the Ischemic Kidney

Intramucosal–arterial PCO2 gap does reflect tissue dysoxia – authors' response

The main criticism of Gutierrez and Turkan [1] to our recent paper [2] is the absence of anaerobic metabolism in the hypoxic hypoxia (HH) group as an explanation for lack of increase in intramucosal–arterial PCO 2 gradient (∆PCO 2). Despite their elegant arguments, we still believe that the animals in the IH group were in an anaerobic state. Our statement is supported by the following. Although...

Metabolic component of intestinal PCO(2) during dysoxia.

The adequacy of intestinal perfusion during shock and resuscitation might be estimated from intestinal tissue acid-base balance. We examined this idea from the perspective of conventional blood acid-base physicochemistry. As the O(2) supply diminishes with failing blood flow, tissue acid-base changes are first "respiratory, " with CO(2) coming from combustion of fuel and stagnating in the decre...